There is a lot of talk in the Autism community about Supplementing Glutethione. This article does a great job presenting some of reasons not to.
We should also remember that an estimated 30%-50% of mercury toxic people are high cysteine and therfore supplementing with NAC is a no go for them.
NAC is a sulfur compound as such it is a monothiol meaning it has only 1/2 a claw so to speak. When cysteine is in abundance it will “ping” mercury all over the place without actually removing it from the body.
While chelating we should aim at keeping supplemental NAC below 200 mg daily and increase sulfur foods for low cysteine kids.
For high cysteine kids we should avoid NAC and restrict sulfur foods. To increase glutethione we can give glutamate and glycine in a 2:1 ratio.
Of course the best thing we can do to increase glutethione is to give vitamin C at least 4 times throughout the day as it will regenerate glutethione.
Glutathione is made from the amino acids L-cysteine + L-glutamate + glycine. The glutathione the body needs is manufactured in the liver. Much ado is made about supplementing glutathione to counteract the oxidative reactions in the brain occurring in ALS, MS and more. But there are problems with supplementation of glutathione or its precursors. Consider these factors:
When the body has excess nitric oxide it converts to peroxynitrite and this reacts with glutathione to make s-nitrosglutathione (a molecule involved in inflammation and vasodilatation).
Since glutathione is poorly absorbed from the intestines into the blood (and this may be worse in people who have physiological problems, preventing it from doing so), taking the precursors glutamine or N-acetylcysteine in an attempt to manufacture glutathione can backfire. In fact, people working with autistic children have found that the children do not do well on supplemental NAC or glutamine. Migraneurs (known nitric oxide excess leading to excessive vasodilatation and inflammation) will find that intravenous glutathione will cause a migraine of the worst sort (see #1).
- Not Another Autism Diet…..uggg (throughthepuzzle.com)
- Glutathione: The amino acid that prevent oxidative stress in most cells and helps to trap free radicals that can damage DNA and RNA. (blissreturned.wordpress.com)